CEFIGET CAPSULE 400MG:

Cefiget 400mg capsule is a third generation cephalosporin, cefixime. Cefiget 400mg capsule is active against both gram negative and gram positive micro-organisms. Cefiget 400mg capsule works as an anti-bacterial agent by binding to a specific protein called as penicillin binding protein (PBPs) causing the lysis of bacterial cell-wall.

USES:

Cefiget 400mg capsule is indicated for the treatment of following types of anti-bacterial infections:

• Uncomplicated urinary tract infections
• Otitis media.
• Uncomplicated gonorrhea
• Acute bronchitis.
• Pharyngitis and tonsillitis.

CEFIGET 400MG CAPSULE USES IN URDU

Cefiget 400mg capsule درج ذیل قسم کے اینٹی بیکٹیریل انفیکشن کے علاج کے لیے تجویز کیا جاتا ہے:

پیشاب کی نالی کے غیر پیچیدہ انفیکشن

• اوٹائٹس میڈیا۔
• غیر پیچیدہ سوزاک
• شدید برونکائٹس۔
• گرسنیشوت اور ٹنسلائٹس۔

SIDE EFFECTS:

Cefiget 400mg capsule may causes:

• Gastrointestinal disturbance: Diarrhea (if severe diarrhea occurs, cefixime should be discontinued), changes in the color of stool, nausea, abdominal pain, dyspepsia, vomiting, flatulence have been reported. Pseudomembranous colitis has also been reported.
• Central nervous system disturbance: Headache, dizziness, seizures. Hepatic Disorders: Transient rises in liver transaminases, alkaline phosphatase and jaundice can also occur.
• Others: Hypersensitivity reactions which usually subside upon discontinuation of therapy; infrequent and reversible hematological changes; elevation of serum amylase. Increase in prothrombin time has been reported in few patients.

PRECAUTIONS:

• Cephalosporins should be given with caution to penicillin sensitive patients, as there is some evidence of partial cross-allergenicity between the penicillin’s and cephalosporins.
• Cefixime should be administered with caution in patients with markedly impaired renal function.
• Treatment with broad spectrum antibiotics alters the normal flora of the colon and may permit overgrowth of clostridia. Pseudomembranous colitis is associated with the use of broad-spectrum antibiotics (including macrolides, semi-synthetic penicillin’s, lincosamides and cephalosporin’s); it is therefore important to consider its diagnosis in patients who develop diarrhea in association with the use of antibiotics. Symptoms of pseudomembranous colitis may occur during or after antibiotic treatment.
• Broad-spectrum antibiotics such as cefixime should be prescribed with caution in individuals with a history of gastrointestinal disease, particularly colitis.

WHEN NOT TO USE:

Cefixime is contraindicated in:

• Patients with hypersensitivity to any component of this medication.
• Patients with known allergy to the cephalosporin group of antibiotics.
• Children less than six months old as safety and efficacy of cefixime in these patients have not been established

INTERACTIONS:

Anticoagulants:  Care should be exercised in patients receiving anticoagulants and cefixime concomitantly due to the possibility that cefixime may increase prothrombin time. Carbamazepine: Elevated carbamazepine levels have been reported, when cefexime is administered concomitantly. Drug monitoring may be of assistance in detecting alterations in carbamazepine plasma concentrations

DOSE:

The recommended adult dose of Cefiget 400mg capsule is 200 - 400mg daily according to the severity of infection, given either as a single dose or in two divided doses

DISCLAIMER 

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• Consult your doctor or pharmacist if you have an underlying medical condition, are taking any other medication or complementary therapy, or if symptoms persist.
• Please read the enclosed instruction leaflet.
• Keep out of reach of children.