DEPO-MEDROL VIAL 40MG/ML
- Medicine Overview
WHAT IS DEPO-MEDROL 40MG/ML VIAL?
DEPO-MEDROL contains methylprednisolone acetate. It is an anti-inflammatory glucocorticoid for intramuscular, intra-articular, soft tissue or intralesional injection. It is available as single-dose vials in two strengths: 40 mg/mL, 80 mg/mL.
WHAT ARE THE USES OF DEPO-MEDROL 40MG/ML VIAL?
Depo-Medrol is used to treat many different inflammatory conditions such as arthritis, lupus, psoriasis, ulcerative colitis, allergic disorders, gland (endocrine) disorders, and conditions that affect the skin, eyes, lungs, stomach, nervous system, or blood cells.
DEPO-MEDROL 40MG/ML VIAL USES IN URDU
Depo-Medrol کا استعمال کئی مختلف اشتعال انگیز حالات جیسے گٹھیا، lupus، psoriasis، ulcerative colitis، الرجک عوارض، غدود (endocrine) کے عوارض، اور جلد، آنکھوں، پھیپھڑوں، معدہ، اعصابی نظام، یا خون کے خلیات کو متاثر کرنے والے حالات کے علاج کے لیے کیا جاتا ہے۔ .
WHAT ARE THE SIDE EFFECTS OF DEPO-MEDROL 40MG/ML VIAL?
The side effects include: HPA axis suppression, increased susceptibility to infection, glaucoma, cataracts, secondary infections, hypokalemia, hypocalcemia, hypernatremia, hypertension, CHF, psychic disorders, myopathy, osteoporosis, peptic ulcer, dermal atrophy, increased intracranial pressure, carbohydrate intolerance. Parenteral: atrophy, flare at site; intrasynovial: septic arthritis.
WHEN NOT TO USE DEPO-MEDROL 40MG/ML VIAL?
- DEPO-MEDROL should not be used in patients with known hypersensitivity to the product and its constituents.
- Intramuscular corticosteroid preparations are contraindicated for idiopathic thrombocytopenic purpura.
- It is not used for intrathecal administration. This formulation of methylprednisolone acetate has been associated with reports of severe medical events when administered by this route.
- It is not used in systemic fungal infections, except when administered as an intra-articular injection for localized joint conditions.
WHAT ARE THE PRECAUTIONS OF DEPO-MEDROL 40MG/ML VIAL?
- These agents should be used with caution in patients with congestive heart failure or renal insufficiency.
- Steroids should be used with caution in active or latent peptic ulcers, diverticulitis, fresh intestinal anastomoses, and nonspecific ulcerative colitis.
- Intraocular pressure may become elevated in some individuals. If steroid therapy is continued long-term, intraocular pressure should be monitored.
WHAT ARE THE INTERACTIONS DEPO-MEDROL 40MG/ML VIAL?
- Potentiated by CYP3A4 inhibitors (eg, ketoconazole, macrolides), cyclosporine, estrogens.
- Antagonized by CYP3A4 inducers (eg, barbiturates, phenytoin, carbamazepine, rifampin), cholestyramine.
- May potentiate cyclosporine (seizure risk).
- May antagonize oral anticoagulants (monitor), isoniazid.
- Increased risk of arrhythmias with digitalis.
- May need to adjust dose of antidiabetic agents.
- Monitor for hypokalemia with potassium-depleting drugs (eg, amphotericin B, diuretics).
- Concomitant neuromuscular blocking agents; increased risk of myopathy.
- Withdraw anticholinesterase agents at least 24hrs before initiating corticosteroid therapy.
- Aminoglutethimide may lead to loss of corticosteroid-induced adrenal suppression.
- Increased GI effects with aspirin, other NSAIDs. Caution with aspirin in hypoprothrombinemia.
WHAT IS THE DOSE OF DEPO-MEDROL 40MG/ML VIAL?
ADULT DOSAGE: Individualize. Locally: 4–80mg. Systemically: 40–120mg IM/week for 1–4 weeks.
CHILD DOSAGE: Individualize. Initially 0.11–1.6mg/kg/day.
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