HCQ 200MG TABLET:

HCQ 200 (Hydroxychloroquine sulfate) is a 4-aminoquinoline mainly used in the treatment of rheumatoid arthritis, systemic and discoid lupus erythematosus. Hydroxychloroquine sulfate is considered a disease modifying anti-rheumatic drug (DMARD) because it not only can decrease the pain and swelling of arthritis but may also prevent joint damage and reduce the risk of long-term disability.

USES:

HCQ 200 (Hydroxychloroquine sulfate) is indicated for the treatment of:

• Active rheumatoid arthritis (including juvenile idiopathic arthritis).
• Systemic and discoid lupus erythematosus.
• Dermatological conditions caused or aggravated by sunlight.

SIDE EFFECTS:

The side-effects of hydroxychloroquine includes gastro-intestinal disturbances, headache and skin reactions (rashes, pruritus); those occurring less frequently include convulsions, visual changes, keratopathy, ototoxicity, hair depigmentation, hair loss and discoloration of skin, nails, and mucous membranes.

PRECAUTIONS:

• The drug should be used with caution in neurological disorders
• In the treatment of rheumatoid arthritis, if objective improvement does not occur within six months, the drug should be discontinued.
• Use of hydroxychloroquine in patients with psoriasis may precipitate a severe attack of psoriasis.
• Periodic blood cell counts should be made if patients are given prolonged therapy.
• Hydroxychloroquine may exacerbate psoriasis and aggravate myasthenia gravis.

WHEN NO TO USE:

Hydroxychloroquine is contraindicated in:

• Patients with known hypersensitivity to 4-aminoquinoline compounds.
• Patients with pre-existing maculopathy of the eye.
• Long-term therapy in children.
• Children under 6 years of age.

INTERACTIONS:

• Hydroxychloroquine possibly inhibits effect of alfa and beta agalsidase and also laronidase.
• Increased risk of ventricular arrhythmias when hydroxychloroquine given in combinations avoid its concomitant use.
• In case of lanthanum it should be given at least 2 hours apart.
• Hydroxychloroquine increases plasma concentration of cyclosporine and digoxin.
• Metabolism of hydroxychloroquine inhibited by Cimetidine.
• Hydroxychloroquine have potential to increase symptoms of myasthenia gravis and thus diminish effects of neostigmine and pyridostigmine.

DOSE:

A suitable initial dose of HCQ 200 tablet is 400mg to 600mg (2 or 3 tablets) daily, preferably taken at meal times. Four to twelve weeks therapy is required before the effect of treatment can be evaluated.

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• Consult your doctor or pharmacist if you have an underlying medical condition, are taking any other medication or complementary therapy, or if symptoms persist.
• Please read the enclosed instruction leaflet.
• Keep out of reach of children.