NEXUM 40MG CAP
- Medicine Overview
NEXUM 40MG CAPSULE:
Nexum 40mg capsules are an enteric-coated pellet formulation of esomeprazole magnesium due to its acid labile nature. Nexum 40mg capsules belongs to the class of drug Proton pump Inhibitor i.e. Esomeprazole that suppresses gastric acid secretion by specific inhibition of the H+/K+-ATPase in the gastric parietal cell.
Nexum 40mg tablet is indicated for the following purpose:
1.Treatment of Gastroesophageal Reflux Disease (GERD)
- Healing of Erosive Esophagitis
- Maintenance of Healing of Erosive Esophagitis
- Symptomatic Gastroesophageal Reflux Disease
- Risk Reduction of NSAID-Associated Gastric Ulcer
- H. pylori Eradication to Reduce the Risk of Duodenal Ulcer Recurrence.
- As a triple therapy (Esomeprazole plus amoxicillin and clarithromycin) is indicated for the treatment of patients with H. pylori infection and duodenal ulcer disease to eradicate H. pylori.
NEXUM 40MG CAPSULE USES IN URDU
Nexum 40mg کی گولی درج ذیل مقصد کے لیے تجویز کی جاتی ہے:
- Gastroesophageal Reflux Disease (GERD) کا علاج
Erosive Esophagitis کی شفا یابی
Erosive Esophagitis کی شفا یابی کی بحالی
- علامتی Gastroesophageal Reflux بیماری
- NSAID سے وابستہ گیسٹرک السر کے خطرے میں کمی
- گرہنی کے السر کی تکرار کے خطرے کو کم کرنے کے لیے H. pylori Eradication۔
- ٹرپل تھراپی کے طور پر (Esomeprazole پلس amoxicillin اور clarithromycin) H. pylori انفیکشن اور گرہنی کے السر کی بیماری کے مریضوں کے علاج کے لیے H. pylori کو ختم کرنے کے لیے اشارہ کیا جاتا ہے۔
Nexum 40mg capsules includes Headache, abdominal pain, constipation, diarrhea, flatulence and nausea/vomiting.
Nexum 40mg capsules are caustiously used in the following conditions:
- Atrophic gastritis has been noted occasionally in gastric corpus biopsies from patients treated long-term with omeprazole, of which esomeprazole is an enantiomer.
- Proton pump Inhibitor may be associated with an increased risk of Clostridium difficile associated diarrhea, especially in hospitalized patients.
WHEN NOT TO USE:
Nexum 40mg capsules are contraindicated in:
- Patients with known hypersensitivity to Proton Pump Inhibitor or substituted benzimidazoles or any excipient of the product.
- Esomeprazole should not be used concomitantly with nelfinavir.
Nexum 40mg capsules shows interactions with the following:
- Co-administration of atazanavir with proton pump inhibitors is expected to substantially decrease atazanavir plasma concentrations and may result in a loss of therapeutic effect and the development of drug resistance.
- Co-administration of saquinavir with proton pump inhibitors is expected to increase saquinavir concentrations, which may increase toxicity and require dose reduction.
- In common with the use of other inhibitors of acid secretion or antacids, the absorption of ketoconazole and itraconazole can decrease during treatment with esomeprazole due to decreased intragastric acidity during treatment with esomeprazole.
- Esomeprazole inhibits CYP2C19, the major esomeprazole metabolising enzyme. Thus, when esomeprazole is combined with drugs metabolised by CYP2C19, such as diazepam, citalopram, imipramine, clomipramine, phenytoin etc., the plasma concentrations of these drugs may be increased and a dose reduction could be needed.
- Drug-induced decrease in gastric acidity results in enterochromaffinlike cell hyperplasia and increased Chromogranin A levels which may interfere with investigations for neuroendocrine tumors.
Nexum 40mg capsules should be swallowed whole and taken at least one hour before meals. The daily recommended dose is 20-40mg daily.
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