RISEK 20MG CAP
RISEK 20MG CAPSULE:
Risek 20mg capsule is a substituted benzimidazole, is a proton pump inhibitor that inhibits gastric acid secretion. Risek 20mg inhibits secretion of gastric acid by irreversibly blocking the enzyme system of hydrogen/potassium adenosine triphosphatase (H+/K+ ATPase), the proton pump of the gastric parietal cell. This effect is dose-related and leads to inhibition of both basal and stimulated acid secretion irrespective of the stimulus.
Risek 20mg capsule is indicated for:
1.Gastro-Esophageal Reflux Disease (GERD):
- Treatment of erosive reflux esophagitis.
- Long term management of patients with healed esophagitis to prevent relapse.
- Symptomatic treatment of gastroesophageal reflux disease (GERD).
- Gastric and duodenal ulcer.
- Treatment and prophylaxis of NSAID-associated ulceration.
- Eradication of Helicobacter pylori infection associated with peptic ulcer disease.
- Zollinger-Ellison syndrome.
- Prophylaxis of acid aspiration.
Risek 20mg capsule is well tolerated and the adverse reactions have generally been mild and reversible. The common side effect include Headache. Other include: Diarrhea, constipation, abdominal pain, nausea/vomiting and flatulence.
WHEN NOT TO USE:
Risek 20mg capsule is contraindicated in patients with known hypersensitivity to any component of the formulation or to substituted.
Risek 20mg capsule is cautiously used in patients with:
- When gastric ulcer is suspected, the possibility of malignancy should be excluded as treatment may alleviate symptoms and delay diagnosis.
- Prior to initiation of dual or triple therapy, the physician should consider the patient with known hypersensitivity reactions to penicillin, macrolides and other antibiotics.
- Omeprazole, as all acid-blocking medicines, may reduce the absorption of vitamin B12 (cyanocobalamin) due to hypo- or achlorhydria. This should be considered in patients with reduced body stores or risk factors for reduced vitamin B12 absorption on long-term therapy.
- Severe hypomagnesemia has been reported in patients treated with proton pump inhibitors (PPIs) like omeprazole for at least three months, and in most cases for a year.
- Proton pump inhibitors, especially if used in high doses and over long durations of greater than one year, may modestly increase the risk of hip, wrist and spine fracture, predominantly in the elderly or in presence of other recognized risk factors.
Risek 20mg capsule may interact with:
- In common with the use of other inhibitors of acid secretion or antacids, the absorption of ketoconazole and itraconazole can decrease during treatment with omeprazole due to decreased intragastric acidity during treatment with omeprazole.
- Omeprazole is metabolized by CYP2C19. Thus, when omeprazole is combined with drugs metabolised by CYP2C19, such as diazepam, citalopram, imipramine, clomipramine, phenytoin etc., the plasma concentrations of these drugs may be increased and a dose reduction could be needed.
- The plasma levels of atazanavir are decreased in case of co-administration with omeprazole therefore concomitant administration of omeprazole with atazanavir is not recommended.
- Concomitant treatment with omeprazole (20mg daily) and digoxin increased the bioavailability of digoxin by 10%
- Concomitant administration of omeprazole with saquinavir resulted in increased plasma levels up to approximately 70% for saquinavir associated with good tolerability in HIV-infected patients.
The recommended adult oral dose is 20mg daily for up to 4 weeks.
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